Pre‐analytical protocol for measuring Alzheimer's disease biomarkers in fresh CSF
نویسندگان
چکیده
منابع مشابه
CSF Biomarkers for Alzheimer's Disease Diagnosis
Alzheimer's disease (AD) is the most common form of dementia that affects several million people worldwide. The major neuropathological hallmarks of AD are the presence of extracellular amyloid plaques that are composed of Abeta40 and Abeta42 and intracellular neurofibrillary tangles (NFT), which is composed of hyperphosphorylated protein Tau. While the amyloid plaques and NFT could define the ...
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Providing an accurate prognosis in patients suffering from acute central nervous system (CNS) disease is difficult. The extent and location of the primary CNS injury is crucial for mortality and morbidity. Secondary injury adds considerably to the CNS insult. The prognosis in an individual patient depends on the combination of primary and secondary CNS damage together with systemic complication...
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OBJECTIVE Alzheimer disease (AD) and frontotemporal lobar degeneration (FTLD) may have overlapping clinical presentations despite distinct underlying neuropathologies, thus making in vivo diagnosis challenging. In this study, we evaluate the utility of MRI as a noninvasive screening procedure for the differential diagnosis of AD and FTLD. METHODS We recruited 185 patients with a clinically di...
متن کاملCSF Biomarkers
With an ever growing population of aged individuals who are at risk of developing Alzheimer’s disease (AD), there is an urgent need for a sensitive, specific and preferably non-invasive diagnostic standard of disease progression. Diagnosis of AD is still largely based on exclusion criteria of secondary causes and other forms of dementia with similar clinical pictures, than the diagnostic accura...
متن کاملVariability of CSF Alzheimer’s Disease Biomarkers: Implications for Clinical Practice
BACKGROUND Cerebrospinal fluid (CSF) biomarkers are increasingly being used for diagnosis of Alzheimer's disease (AD). OBJECTIVE We investigated the influence of CSF intralaboratory and interlaboratory variability on diagnostic CSF-based AD classification of subjects and identified causes of this variation. METHODS We measured CSF amyloid-β (Aβ) 1-42, total tau (t-tau), and phosphorylated t...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
سال: 2020
ISSN: 2352-8729,2352-8729
DOI: 10.1002/dad2.12137